Hoxworth

Kaiden Isaack

Four-year-old Kaiden Isaack faced more in his short life than most do in a lifetime. Born with complex congenital heart disease, he spent the first eight months of his life hospitalized. It was during that time that Nancy Isaack, her husband Jeff and their family entered his world as foster parents for Hamilton County, caring for medically complex children. While Kaiden is no longer here on Earth, his memory lives on. Nancy explains how Hoxworth blood donors helped Kaiden live a longer life and why they choose to give back to continue Kaiden’s legacy.

How Chemotherapy and Blood Products from Hoxworth Donors Gave Kaiden more Life

Kaiden in the hospital

Kaiden’s health problems started early. Not only was he born with heart issues, at just 14 months old, Kaiden was diagnosed with stage 4 neuroblastoma. “This was a devastating diagnosis by itself,” Nancy shared, “but coupled with heart disease, it felt like the cards were stacked against him.” In August 2021, Kaiden began chemotherapy every three weeks for 11 cycles. During chemo, he received red cells once a month and platelets two to three times each week for the last year of his life. All of this possible thanks to blood donors with Hoxworth. Nancy says each time he received blood, he was able to be off oxygen for a few days. She says the combination of red cells and platelets no doubt prolonged his life.

The treatments were grueling, but in May 2022, he reached a milestone his family had prayed for when he rang the bell, signifying the end of treatment. He had overcome neuroblastoma. “This felt like a huge victory,” Nancy said.

A Life of Joy and Sorrow

Kaiden in the hospital close up

For about six months, Kaiden was able to enjoy a stretch of stability. In May 2023, he was officially adopted into the Isaack family! This was a joyful chapter after months of hospitalizations and uncertainty. But their celebration was short-lived.

After countless tests and frequent hospital stays, doctors delivered heartbreaking news: Kaiden had developed a secondary cancer, myelodysplastic syndrome (MDS), in his blood and bone marrow. The sad irony is this cancer was a result of the very chemotherapy that had saved his life.

A bone marrow transplant offered a potential cure, but because of his underlying heart disease, Kaiden was not a candidate. “He couldn’t be cured,” Nancy said. He endured many more months of palliative chemotherapy as his health steadily declined. On August 28, 2024, at the age of four, Kaiden passed away.

Smiling Through it All

Kaiden on the bed at home

Despite his struggles, Kaiden’s spirit never dimmed. “Kaiden was probably the toughest and strongest boy that we know,” Nancy said. “He had an uncanny ability to smile and find joy, even on his hardest days.” Though he didn’t use many words, he communicated clearly and powerfully. “He had the best laugh and executed the perfect side-eye when he thought something fishy was happening,” she remembered.

Everyone who met him was drawn to his exuberant personality. He loved boating and being on the water, anything related to Mickey Mouse, and many Disney movies. Most of all, he loved his family and they loved him fiercely.

Leaving Behind a Legacy of Love

Kaiden smiling at the hospital

Kaiden’s life was far too short, but it was filled with deep love and extraordinary courage. Because of the Isaack family’s close proximity to his exceptional care team at Cincinnati Children’s Hospital and the lifesaving blood and platelet transfusions he received, Kaiden was able to spend meaningful, quality time at home.

“He was so loved by his family,” Nancy said, “and we will always be grateful for the blood and platelet donors that helped him along the way.”

Kaiden’s Memorial Blood Drive

Started in 2025 just a year after Kaiden died, Nancy and her family organized a memorial blood drive with Hoxworth to honor Kaiden and help local patients in Cincinnati area hospitals. Throughout his life and during his time at Cincinnati Children’s Hospital, Kaiden received 237 blood transfusions. Nancy says she knows there are families just like hers that have a loved one receiving blood and platelets in the hospital right now. Every five minutes someone in the Tri-State needs blood. Can you help these patients?